Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition 2010 Aug 4. [Epub ahead of print]
PMID: 20688474
doi:10.1016/j.nut.2010.05.016
http://linkinghub.elsevier.com/retrieve/pii/S0899-9007(10)00174-7
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Nutrition. 2010 Aug 4. [Epub ahead of print]
Vitamin C provision improves mood in acutely hospitalized patients.
Zhang M, Robitaille L, Eintracht S, Hoffer LJ.
Lady Davis Institute for Medical Research, McGill University, and Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada.
Abstract
OBJECTIVE: Hypovitaminosis C and D are highly prevalent in acutely hospitalized patients, but the clinical significance of these biochemical abnormalities is not known. Because deficiencies of vitamin C and D have been linked to psychologic abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients.
METHODS: Double-blind clinical trial of the effect of vitamin C (500 mg twice daily) or vitamin D (1000 IU twice daily) on mood, as assessed with a validated instrument, the Profile of Mood States.
RESULTS: Vitamin C therapy increased plasma (P < 0.0001) and mononuclear leukocyte (P = 0.014) vitamin C concentrations and was associated with a 34% reduction in mood disturbance (P = 0.013). Vitamin D therapy increased plasma 25-hydroxyvitamin D concentrations (P = 0.0004), but had no significant effect on mood.
CONCLUSIONS: Treatment of hypovitaminosis C improves the mood state of acutely hospitalized patients.
PMID: 20688474