Henker J, Laass MW, Blokhin BM, et al. Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers. Pediatr Infect Dis J 2008 Jun;27(6):494-499.
http://www.pidj.com/pt/re/pidj/abstract.00006454-200806000-00003.htm
http://www.pidj.com/pt/re/pidj/fulltext.00006454-200806000-00003.htm
http://www.pidj.com/pt/re/pidj/pdfhandler.00006454-200806000-00003.pdf
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Pediatr Infect Dis J. 2008 Jun;27(6):494-9.
Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers.
Henker J, Laass MW, Blokhin BM, Maydannik VG, Bolbot YK, Elze M, Wolff C, Schreiner A, Schulze J.
Department of Pediatrics, University Carl-Gustav-Carus, Dresden, Germany.
BACKGROUND: Administering probiotics can prevent or cure some forms of diarrhea. The efficacy of probiotic Escherichia coli Nissle 1917 (EcN) in infants and toddlers with diarrhea >4 days was tested by a double-blind trial. METHODS: One hundred fifty-one children aged 1-47 months with nonspecific diarrhea were randomized to receive either EcN suspension (N = 75) or placebo (N = 76). Diarrhea had to meet the following definition: >3 watery or loose nonbloody stools in 24 hours of a diarrheal episode persisting for >4 consecutive days but or =4 days) with EcN. RESULTS: The 7-day response was higher for the EcN group than placebo (EcN 78.7%, placebo 59.2%). Significant differences were observed on days 14 (EcN 93.3%, placebo 65.8%, P = 0.0017) and 21 (EcN 98.7%, placebo 71.1%, P 4 days in young children.
PMID: 18469732