Wright MJ, Sullivan RR, Gaffney-Stomberg E, et al. Inhibiting gastric acid production does not affect intestinal calcium absorption in young healthy individuals: a randomized, crossover controlled clinical trial. J Bone Miner Res 2010 Apr 7. [Epub ahead of print]
DOI: 10.1002/jbmr.108
PMID: 20499372
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.108/abstract
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.108/full
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.108/pdf
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J Bone Miner Res. 2010 Apr 7. [Epub ahead of print]
Inhibiting gastric acid production does not affect intestinal calcium absorption in young healthy individuals: a randomized, crossover controlled clinical trial.
Wright MJ, Sullivan RR, Gaffney-Stomberg E, Caseria DM, O'Brien KO, Proctor DD, Simpson CA, Kerstetter JE, Insogna KL.
Department of Allied Health Sciences, University of Connecticut Storrs, CT (MJW, JEK).
Abstract
INTRODUCTION: Proton pump inhibitors (PPIs) are the most potent gastric acid suppressing drugs available and their use is widespread. An emerging concern about chronic PPI therapy is whether these drugs impair intestinal calcium absorption, resulting in a negative calcium balance and thereby potentially causing bone loss. The objective of the study was to evaluate the acute effect of a proton pump inhibitor (PPI) omeprazole, or placebo, on intestinal calcium absorption in healthy adults.
MATERIALS AND METHODS: Twelve young adults participated in a placebo-controlled, double-blind, cross-over study. There were two 3-week interventions that included a 14-day adjustment period (designed to stabilize calcium homeostasis) followed by 6 days of a diet containing 800 mg of calcium and 2.1 g/kg protein (intervention). During the last three days of the adjustment period and throughout the intervention period, subjects consumed omeprazole or placebo. Half of the subjects underwent 24 h continuous gastric acid pH monitoring. Intestinal calcium absorption was measured using dual-stable calcium isotopes at the end of each intervention.
RESULTS: Treatment with omeprazole significantly increased gastric pH (mean pH on PPI: 5.38 +/- 0.13; mean pH on placebo: 2.70 +/- 0.44, p = 0.005). Neither calcium absorption (PPI: 34.2 +/- 2.4%; placebo: 31.5 +/- 2.1%, p = 0.24) nor urinary calcium (PPI: 321 +/- 38 mg/34 hrs; placebo: 355 +/- 37 mg/34 hrs, p = 0.07) differed between the PPI and placebo treatment.
CONCLUSION: Short-term gastric acid suppression by PPIs does not attenuate intestinal calcium absorption in healthy young adults.
(c) 2010 American Society for Bone and Mineral Research.
PMID: 20499372