Petersen SG, Saxne T, Heinegard D, et al. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage. 2009 Jul 15.
doi:10.1016/j.joca.2009.07.004   ÂÂ
http://linkinghub.elsevier.com/retrieve/pii/S1063-4584(09)00183-6
Key words:
Glucosamine; Dietary supplement; NSAID; Ibuprofen; Exercise; Knee osteoarthritis; Cartilage oligomeric matrix protein; c-Telopeptide of type II collagen
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Osteoarthritis Cartilage. 2009 Jul 15. [Epub ahead of print]
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training.
Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M.
Institute of Sports Medicine Copenhagen and Center for Healthy Aging, Faculty of Health Sciences, Bispebjerg Hospital, DK-2400NV, University of Copenhagen, Denmark.
OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo. DESIGN: A 12-week double blind, placebo controlled, randomized study. METHOD: Thirty-six elderly patients with bilateral tibiofemoral knee OA determined by radiography were randomly assigned to treatment with glucosamine (n=12), ibuprofen (n=12) or placebo (n=12) during 12 weeks of strength training of both legs with focus on the quadriceps muscle. Strength tests (5 repetition maximum), blood and urine sampling were performed before and after the training period. Serum COMP and urinary CTX-II were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: All three groups increased their muscle strength following 12 weeks of strength training (P
PMID: 19679221