Ghavami G, Sardari S, Ali Shokrgozar M. Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/CP cell lines. Comput Biol Med 2011 Jul 11. [Epub ahead of print]
PMID: 21752359
doi:10.1016/j.compbiomed.2011.06.002
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Comput Biol Med. 2011 Jul 11. [Epub ahead of print]
Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/CP cell lines.
Ghavami G, Sardari S, Ali Shokrgozar M.
Source
Drug Design and Bioinformatics Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, #69, Pasteur Avenue, P.O. Box 1316943551, Tehran, Iran; Eastern Mediterranean Health Genomics and Biotechnology Network (EMGEN), #69, Pasteur Avenue, Tehran 13164, Iran.
Abstract
The treatment of cancer usually involves lethal effect on normal body cells as side effects. Cheminformatics methodology can play a significant role in biomed/clinical scientific research. Similarity searching is a standard cheminformatics tool in drug discovery area and database design. In this study, five novel herbal extracts in combination with doxorubicin and cisplatin have been used to sensitize ACHN and A2780/cp cells. These herbal extracts have been selected on the basis of novel cheminformatics methodology and assayed for the first time. The findings confirmed predicted outcomes from the in silico research and the results introduced may bring to use the effects of these herbs in reversing of multidrug resistance (MDR) phenomenon.
Copyright © 2011 Elsevier Ltd. All rights reserved.
PMID: 21752359