Beasley RW, Clayton TO, Crane J, et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: ISAAC Phase Three. Am J Respir Crit Care Med 2010 Aug 13. [Epub ahead of print]
PMID: 20709817
DOI: 10.1164/rccm.201005-0757OC
http://ajrccm.atsjournals.org/cgi/content/abstract/201005-0757OCv1
http://ajrccm.atsjournals.org/cgi/reprint/201005-0757OCv1
related:
Amberbir A, et al. The role of acetaminophen and geohelminth infection on that incidence of wheeze and eczema: A longitudinal birth-cohort study. Am J Respir Crit Care Med 2010.
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Am J Respir Crit Care Med. 2010 Aug 13. [Epub ahead of print]
Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis and Eczema in Adolescents: ISAAC Phase Three.
Beasley RW, Clayton TO, Crane J, Lai CK, Montefort SR, von Mutius E, Stewart AW; the ISAAC Phase Three Study Group.
Medical Research Institute of New Zealand, Wellington, New Zealand.
Abstract
RATIONALE: There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma.
OBJECTIVE: To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13 to 14 year old children in different populations worldwide.
METHODS: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13 to 14 year old children completed written and video questionnaires, obtaining data on current symptoms of asthma, rhinoconjunctivitis and eczema, and a written environmental questionnaire obtaining data on putative risk factors including acetaminophen use in the past 12 months.
MEASUREMENTS: The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression.
MAIN RESULTS: A total of 322,959 adolescent children from 113 centres in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthma symptoms [OR 1.43 (95% CI 1.33 to 1.53) and 2.51 (95% CI 2.33 to 2.70) for medium and high versus no use respectively]. Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema.
CONCLUSIONS: Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis and eczema in adolescent children.
PMID: 20709817