Huang W, Ye X, Li X, et al. [The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase]. Zhongguo Zhong Yao Za Zhi 2010 Sep;35(18):2428-2431. [Chinese]
PMID: 21141493
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Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(18):2428-31.
[The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase].
[Article in Chinese]
Huang W, Ye X, Li X, Zhao Z, Lan P, Wang L, Liu M, Gao Y, Zhu J, Li P, Feng P.
Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University, Chongqing 400716, China.
Abstract
OBJECTIVE: To study the hypolipidemic active compounds from Crataegus pinnatifida and mechanism of action of those.
METHOD: Guided by the inhibitory activity to HMG-CoA reductase, the active compounds were separated and purified with macroporous resin and silica gel.
RESULT: Four active compounds were obtained, which were quercetin, hyperoside, rutin and chlorogenic acid, the sum of their inhibitory rate was 50.01%, and the total inhibitory rate of the mixture of four active compounds matched was 79.48%.
CONCLUSION: Quercetin and hyperoside were the principle active components inhibiting HMG-CoA reductase in Hawthorn fruit, and there were synergistic action among them.
PMID: 21141493