Pharmacogenomics: will the promise be fulfilled? Nature Rev Genetics 2011

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Wed, 12/29/2010 - 22:39
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Pharmacogenomics: will the promise be fulfilled? Nature Rev Genetics 2011

 

Altman RB, Kroemer HK, McCarty CA, et al. Pharmacogenomics: will the promise be fulfilled? Nature Rev Genetics 2011 Jan;12(1):69-73.  (Review)
 
PMID: 21116304
doi:10.1038/nrg2920
 
 
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Perspectives
Nature Reviews Genetics 12, 69-73 (January 2011) | doi:10.1038/nrg2920
VIEWPOINT
Pharmacogenomics: will the promise be fulfilled?
Russ B. Altman, Heyo K. Kroemer, Catherine A. McCarty, Mark J. Ratain & Dan Roden  

Abstract
Tools such as genome resequencing and genome-wide association studies have recently been used to uncover a number of variants that affect drug toxicity and efficacy, as well as potential drug targets. But how much closer are we to incorporating pharmacogenomics into routine clinical practice? Five experts discuss how far we have come, and highlight the technological, informatics, educational and practical obstacles that stand in the way of realizing genome-driven medicine.

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