Chiu CJ, Klein R, Milton RC, et al. Does eating particular diets alter risk of age-related macular degeneration in users of the age-related eye disease study supplements? Br J Ophthalmol 2009 Jun 12. [Epub ahead of print]
http://bjo.bmj.com/cgi/content/abstract/bjo.2008.143412v2
http://bjo.bmj.com/cgi/rapidpdf/bjo.2008.143412v2
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Br J Ophthalmol. 2009 Jun 12. [Epub ahead of print]
Does eating particular diets alter risk of age-related macular degeneration in users of the age-related eye disease study supplements?
Chiu CJ, Klein R, Milton RC, Gensler G, Taylor A.
United States.
BACKGROUND: Recent information suggests that the Age-Related Eye Disease Study (AREDS) supplement, enhanced intake of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and reducing dietary glycemic index (dGI) are protective against advanced age-related macular degeneration (AMD). METHODS: Dietary information was collected at baseline and fundus photograph grades were obtained during the 8-y trial period from 2,924 eligible AREDS AMD trial participants. Using eye as the unit of analysis and multi-failure Cox proportional-hazards regression, we related the risk of AMD progression to dietary intake in the four arms of the trial. RESULTS: Independent of AREDS supplementation, higher intakes of DHA (>/= 64.0 vs. /= 42.3 vs. /= 81.5) (HR = 0.76, 95% CI, 0.60, 0.96) were associated with lower risk for progression to advanced AMD. Participants consuming lower dGI and higher DHA or EPA had the lowest risk (P for synergistic interaction
PMID: 19508997